A study of mice reveals reasons ketidakmanjuran stress drugs or anti-depressants to half of penggunannya in the United States (U.S.).
Many anti-depressant drugs commonly used, such as Prozac and Zoloft, work by increasing the amount of serotonin, a hormone that is chemically into the brain is carried by cells known as neural layer.
Researchers from Columbia University medical center in New York on Wednesday (13 / 1) local time to say, the genetically engineered mice that have more to one recipient hormone serotonin in brain areas would respond to anti-slow depressan.
"Recipients of this work inhibit the production of serotonin nerve. Too many more receptors will inhibit nerves," said Rene Hen, whose research is in the journal nerve when Reuters in a telephone interview.
"It's too much blocking system works," said Hen, whose research provides input to the physician if a patient has a drug in response to stress.
In addition, research can help drug manufacturers to better perform a clinical trial as well as help discover new drugs compounds that are useful for people who do not like the benefits of regular anti-stress.
"The goal is to find out something useful for those who do not get change," he said.
For his research, Hen and other researchers at the receiver requires the achievement of serotonin only in the appropriate section in the brain.
To do so, the research team on the one hand menggunakkan mice that are genetically changed to have only a few recipients of serotonin in the nerve layer in the production of serotonin.
On the other hand, other researchers menggunakkan recipient mice with levels of serotonin in different parts of the brain, they test the behavior of rats by seeing the courage to take food in a bright area.
Mice that were given stress reliever medication is usually more daring, but it was not proven in the recipient mice with an excess of serotonin.
"The most dramatic discovery occurred in mice with a high acceptance rate in the serotonin nerves did not respond to fluoxetine, or Prozac," says Hen.
When they reduce the number of recipients that were able to reverse its effects, he said.
"By reducing the number of recipients, we are able to change a not respond to respond," said Hen.
There are at least approximately 27 million who use the drug in the U.S. stress, ie close to two times the amount in the mid-1990s.
Eli Lilly and representatives of Prozac, also known by fluoxetinenya, Zoloft, and Pfizer Inc., the pioneer of anti-selective depressan famous, had pulled back the growth-preventing substance, or SSRIs.
Meanwhile, the general stress reliever drugs, including Forest Laboratories Inc's Celexa, or citalopram and lexapro or escitalopram; and GlaxoSmithKline's Paxil, or paroxetine, also doing the same thing.
